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  • About us
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About us

  • Tetraneuron
  • Our history
  • Tetraneuron
  • Our history

Rewiring hope: pioneering gene therapy to reverse neurodegeneration.

  • About Tetraneuron

    Our dedication to research and commitment to neurological health place us at the forefront of science and medicine, with a clear mission: to improve the lives of those facing these devastating conditions.

    At Tetraneuron, we believe in a future where neurodegenerative diseases no longer signify relentless suffering and decline. Instead, we envision personalized and effective therapies that bring hope and enhance quality of life. This dream is what drives us to work tirelessly every day.
  • Our mission

    Our mission is to revolutionize the landscape of neurodegenerative diseases by providing safe and effective gene therapies targeting disorders like Alzheimer's and other aging-related neurodegenerative conditions. We're dedicated to scientific excellence and ethical standards at every stage of our journey.
  • Our Experience

    At Tetraneuron, our team consists of scientists and biotechnology experts who have dedicated their careers to researching and developing gene therapies for neurodegenerative diseases. With our expertise in neuroscience and technology, we approach complex medical challenges in innovative ways.
A Tetraneuron employee wearing a mask

Our team

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Ángel Lucio Pereira
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Ángel Lucio Pereira

CEO

José M. Frade. PhD
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José M. Frade. PhD

Co-Founder and Chief Scientific Officer

Manuel Nunez
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Manuel Nuñez González

Chairman & Co-Founder

Álvaro Pascual-Leone. MD.PhD
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Álvaro Pascual-Leone. MD.PhD

Translational and Clinical Science Lead

Mari Carmen Álvarez. PhD
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Mari Carmen Álvarez. PhD

Managing Director

Mar Municio. PhD
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Mar Municio. PhD

R&D Director

Noelia López Sánchez
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Noelia López Sánchez. PhD

Technical Director

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José M. Frade. PhD
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José M. Frade. PhD

Co-Founder and Chief Scientific Officer

Álvaro Pascual-Leone. MD.PhD
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Álvaro Pascual-Leone. MD.PhD

Translational and Clinical Science Lead

Pedro Bermejo
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Pedro Bermejo, MD, PhD

Scientific Adviser

Teodoro del Ser. MD. PhD
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Teodoro del Ser. MD. PhD

Senior Clinical Adviser

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Neil Thomas

IP Strategic Adviser

David Mor
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David Mor

Financial Adviser

Alonso Fernández Nistal, PhD
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Alonso Fernández Nistal, PhD

Strategic Adviser

Pasquale Monteleone
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Pasquale Monteleone

Senior Communications Adviser

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Cristina Sánchez Puelles. PhD
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Cristina Sánchez Puelles. PhD

Senior Researcher

Alberto Garrido
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Alberto Garrido

Laboratory Technician

Vanesa Cano
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Vanesa Cano

Laboratory Technician

Alicia Hernandez Vivanco
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Alicia Hernandez Vivanco

Postdoctoral Researcher

Irene Camacho
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Irene Camacho

PhD. Student

Our history

2023

New strategic alliances in Parkinson and aging

2022

Pre-IND meeting with the FDA

2021

Beginning of the preclinical regulatory phase

2020

Method of validation of TET-101

2019

Analysis of biological processes modulated by E2F4DN

2018

Validation of the Leading Compound

2017

Validation of the Leading Compound

2016

Identification of the Leading Compound

2015

Validation of the therapeutical target E2F4DN

2014

Beginning of the proof of concept

2013

Identification of the therapeutical target E2F4

2012

Tetraneuron was founded

Homage to Santiago Ramón y Cajal

At Tetraneuron, we are honoured to have our scientific roots in the institute where, back in the early 1900s, Santiago Ramón y Cajal developed pioneering research about the fine structure of the nervous system of the brain and spinal cord, allowing him to earn the prestigious Nobel prize in 1906. With more than 100 publications in both Spanish and French and prolific research activities, Ramón y Cajal’s work provided the foundational understanding of neural structure and function, which is critical for comprehending neurological disorders and neurodegeneration. His contribution to the study of neuroscience and neurodegeneration includes the establishment of the “Neuron Doctrine”, which states that neurons are discrete cells and demonstrates that they communicate through junctions (synapses). In the images we share here, Cajal’s offers detailed and artful representations or the brain, feed the mounting evidence about this organ being as vast and mysterious as the universe.

In this pensive portrait, Nobel laureate Santiago Ramón y Cajal sits in his study, surrounded by the tools of his trade. His microscope and chemical bottles offer a rare glimpse into the scientist's workspace.
Spanish neuroscientist Santiago Ramón y Cajal is pictured in profile, deeply engaged with his microscope. This intimate view captures the intense focus of the Nobel laureate often hailed as the father of modern neuroscience.
A formal black and white portrait shows the distinguished Spanish scientist, Santiago Ramón y Cajal. His direct and intense gaze conveys the profound intellect that revolutionised our understanding of the human brain.
An astrocyte in the human hippocampus
Astrocytes in the hippocampus of the human brain
A Purkinje neuron from the human cerebellum
Stellate neurons in the cerebellum
The pyramidal neuron of the cerebral cortex
Neurons in the middle layers of the cerebral cortex
Injured axons of pyramidal neurons in the cerebral cortex
Axons of Purkinje neurons in the cerebellum of a drowned man
Glial cells of a cerebral cortex of a child
Cajal´s preparation Illustrating an astrocyte in the hippocampus, c. 1890
Simulation based on new images captured by an international team of astronomers, 2025 (A. Benítez-Llambay/Univer. Mailand-Bicocca/MPA

Tetraneuron es una empresa biotecnológica española de terapia génica centrada en las enfermedades cerebrales y neurodegenerativas

Con sede en Madrid y Valencia, Tetraneuron nace como spin-off del Instituto Cajal, perteneciente al Consejo Superior de Investigaciones Científicas (CSIC)

Comprometidos con la excelencia científica y la ética en cada paso del camino.

Would you like to know more about Tetraneuron?

CONTACT US
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C/ Velázquez, 154 – Pta Baja Izda A
28002 Madrid, Spain

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