Research

The only gene therapy for Alzheimer’s disease with a multifactorial approach

A gene therapy based on E2F4DN. A promising approach for a disease that affects 50 million people in the world and that has no effective treatment.

Alzheimer and gene therapy in two minutesWatch the video

The science behind our therapy

  • Neurons subjected to stress (excitotoxicity, trophic deprivation, oxidative stress, Aβ, …) increase the expression of the cell cycle regulators.
  • The reentry of the cell cycle leads to the replication of the DNA, tetraploidy and the neuropathological characteristics of Alzheimer’s disease.
  • There are several cell cycle regulators that are risk factors for Alzheimer’s disease. Amongst them is E2F4, a crucial protein for neuronal function.
  • Research carried out by the team at Tetraneuron have shown that in situations of stress, p38Map Kinase phosphorylates E2F4, inhibiting its function, which triggers the appearance of the different neuronal damage present in Alzheimer’s disease.
  • Tetraneuron’s therapy is in a development phase, based on the use of E2F4DN, a negative dominant form of E2F4 that cannot be phosphorylated. In this way, the phosphorylation is prevented and the neuronal tetraploidy is not triggered, which gives rise to improvements in the cognitive functions of Alzheimer mice models.

Lines of research

Tetraneuron is concentrating its research on E2F4, a cell cycle regulator extensively related to Alzheimer’s disease.

Therapy research
Research in biomarkers

TETRANEURON AAV-E2FADN, a multifactorial gene therapy for Alzheimer’s disease

E2F4DN is a modified variant of E2F4 that cannot be phosphorylated. The blocking of this phosphorylation prevents the start of neuronal tetraploidy, restoring the homeostasis and the neuronal function in the brain.

 

TETRANEURON AAV-E2F4 is a safe product that is only expressed under the control of a neuronal promoter, improving several pathological mechanisms of Alzheimer’s disease.

We have developed a disruptive, highly innovative technology, patented in the United States, the European Union and Japan.

Research in biomarkers

Tetraneuron is working on the phosphorylation of E2F4 during the earliest stages of Alzheimer’s disease, analysing the presence of phosphorylated E2F4 in blood serum as an early biomarker for this disease.

This technology has been patented internationally.

Scientific articles

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Collaborating Institutions and Societies