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Breaking new barriers in neuroscience

We are developing a disruptive gene therapy platform addressing the root causes of neurodegenerative conditions through a unique multifactorial approach

Our therapy

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Who we are

Tetraneuron is a biotech company focused on novel gene therapies for Alzheimer’s and other neurodegenerative diseases.

Our groundbreaking therapeutic approach is linked to extensive research carried out at the Cajal Institute in Madrid, affiliated with the Spanish National Research Council (CSIC).

ABOUT US
An illustration of a brain

Tetraneuron is a biotech company focused on novel gene therapies for Alzheimer’s and other neurodegenerative diseases.

Our groundbreaking therapeutic approach is linked to extensive research carried out at the Cajal Institute in Madrid, affiliated with the Spanish National Research Council (CSIC).

ABOUT US

Key milestones

2012

Company foundation

2015

Proof of concept validation

2017

Biomarker patent acquisition

2018

Validation of gene therapy as modality

2020

Validation of the administration route’s proof of concept

2022

Completed preclinical interactions with international regulatory agencies

2023

Seed financial round executed; granted non-dilutive funding for the company

2024

Successful production of the CMC 100L Tox batch

2024

Successful POC Parkinsons data

2025

NHP GLP Preclinical study finalized

2025

New Alzheimer patent submitted

Scientific research areas

A person in a lab creating a sample in a vial.

Tetraneuron focuses its research on E2F4, a protein involved in regulating multiple brain pathways

We’re developing gene therapies aimed at addressing neurodegenerative conditions, reinstating biological processes that have been impacted by the pathogenic phosphorylation of E2F4.

MORE ABOUT OUR R&D

Latest Scientific Papers

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E2F4DN Transgenic Mice: A Tool for the Evaluation of E2F4 as a Therapeutic Target in Neuropathology and Brain Aging (2022)

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A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice (2022)

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E2F4 as a single multifactorial target against Alzheimer’s disease (2021)

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Find out more

Leadership Team

The scientific team has members with over 30 years of experience in neuroscience, along with executives from biopharmaceutical companies as partners.

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Ángel Lucio Pereira
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Ángel Lucio Pereira

CEO

José M. Frade. PhD
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José M. Frade. PhD

Co-Founder and Chief Scientific Officer

Manuel Nunez
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Manuel Nuñez González

Chairman & Co-Founder

Álvaro Pascual-Leone. MD.PhD
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Álvaro Pascual-Leone. MD.PhD

Translational and Clinical Science Lead

Mari Carmen Álvarez. PhD
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Mari Carmen Álvarez. PhD

Managing Director

Mar Municio. PhD
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Mar Municio. PhD

R&D Director

Noelia López Sánchez
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Noelia López Sánchez. PhD

Technical Director

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Would you like to know more about Tetraneuron?

CONTACT US
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C/ Velázquez, 154 – Pta Baja Izda A
28002 Madrid, Spain

Ⓒ Tetraneuron S.L. All Rights Reserved

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