New scientific publication of Tetraneuron

Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer’s-associated neuropathology

The study has recently been accepted and published by the prestigious journal Neurobiology of Aging

This study demonstrates the existence of neuronal tetraploidization in the cerebral cortex associated with age, whose blockage correlates with cognitive improvements in the mice. This tetraploidization associated with aging is also detected in a region of the human brain cortex very important for memory (the entorhinal cortex) and is affected in very early stages of Alzheimer’s. In patients with Alzheimer’s neuronal tetraploidization is also observed in other regions of the cerebral cortex, preceding and recapitulating the neuropathology associated with this pathology.

 

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